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3vtx

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{{STRUCTURE_3vtx| PDB=3vtx | SCENE= }}
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==Crystal structure of MamA protein==
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===Crystal structure of MamA protein===
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<StructureSection load='3vtx' size='340' side='right' caption='[[3vtx]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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{{ABSTRACT_PUBMED_22917855}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vtx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candidatus_magnetobacterium_bavaricum Candidatus magnetobacterium bavaricum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VTX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vty|3vty]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MamA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29290 Candidatus Magnetobacterium bavaricum])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vtx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vtx RCSB], [http://www.ebi.ac.uk/pdbsum/3vtx PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Magnetotactic bacteria enclose the magnetosome, a unique prokaryotic sub-cellular organelle that allows the biomineralization of magnetic nano-crystals. Membrane-coated magnetosomes are arranged into a linear chain that permits magnetotactic bacteria to navigate geomagnetic fields. Magnetosome assembly and biomineralization are controlled by conserved magnetosome-associated proteins, including MamA, a tetra-trico-peptide repeat (TPR)-containing protein that was shown to coat the magnetosome membrane. In this study, two MamA structures from Candidatus Magnetobacterium bavaricum (Mbav) were determined via X-ray crystallography. These structures confirm that Mbav MamA folds as a sequential TPR protein and shares a high degree of structural similarity with homologous MamA proteins from Magnetospirillum species. Furthermore, the two TPR-containing domains of MamA are separated by an interphylum-conserved region containing a flexible hinge that is involved in ligand binding and recognition. Finally, substantial differences were found in the local stabilization of the MamA N-terminal domain as a result of the loss of an evolutionary conserved salt bridge.
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==About this Structure==
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Inter-phylum structural conservation of the magnetosome-associated TPR-containing protein, MamA.,Zeytuni N, Baran D, Davidov G, Zarivach R J Struct Biol. 2012 Dec;180(3):479-87. doi: 10.1016/j.jsb.2012.08.001. Epub 2012 , Aug 15. PMID:22917855<ref>PMID:22917855</ref>
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[[3vtx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candidatus_magnetobacterium_bavaricum Candidatus magnetobacterium bavaricum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTX OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:022917855</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Candidatus magnetobacterium bavaricum]]
[[Category: Candidatus magnetobacterium bavaricum]]
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[[Category: Baran, D.]]
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[[Category: Baran, D]]
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[[Category: Davidov, G.]]
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[[Category: Davidov, G]]
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[[Category: Zarivach, R.]]
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[[Category: Zarivach, R]]
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[[Category: Zeytuni, N.]]
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[[Category: Zeytuni, N]]
[[Category: Peptide binding protein]]
[[Category: Peptide binding protein]]
[[Category: Protein binding]]
[[Category: Protein binding]]

Revision as of 07:37, 21 December 2014

Crystal structure of MamA protein

3vtx, resolution 1.75Å

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