3sir

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{{STRUCTURE_3sir| PDB=3sir | SCENE= }}
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==Crystal Structure of drICE==
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===Crystal Structure of drICE===
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<StructureSection load='3sir' size='340' side='right' caption='[[3sir]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21811237}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SIR FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sir OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sir RCSB], [http://www.ebi.ac.uk/pdbsum/3sir PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Drosophila inhibitor of apoptosis protein DIAP1 exists in an auto-inhibited conformation, unable to suppress the effector caspase drICE. Auto-inhibition is disabled by caspase-mediated cleavage of DIAP1 after Asp20. The cleaved DIAP1 binds to mature drICE, inhibits its protease activity, and, presumably, also targets drICE for ubiquitylation. DIAP1-mediated suppression of drICE is effectively antagonized by the pro-apoptotic proteins Reaper, Hid, and Grim (RHG). Despite rigorous effort, the molecular mechanisms behind these observations are enigmatic. Here we report a 2.4 A crystal structure of uncleaved DIAP1-BIR1, which reveals how the amino-terminal sequences recognize a conserved surface groove in BIR1 to achieve auto-inhibition, and a 3.5 A crystal structure of active drICE bound to cleaved DIAP1-BIR1, which provides a structural explanation to DIAP1-mediated inhibition of drICE. These structures and associated biochemical analyses, together with published reports, define the molecular determinants that govern the interplay among DIAP1, drICE and the RHG proteins.
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==Function==
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Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE.,Li X, Wang J, Shi Y Nat Commun. 2011 Aug 2;2:408. doi: 10.1038/ncomms1418. PMID:21811237<ref>PMID:21811237</ref>
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[[http://www.uniprot.org/uniprot/ICE_DROME ICE_DROME]] Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3sir]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SIR OCA].
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</div>
==See Also==
==See Also==
*[[Caspase|Caspase]]
*[[Caspase|Caspase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021811237</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Li, X.]]
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[[Category: Li, X]]
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[[Category: Shi, Y.]]
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[[Category: Shi, Y]]
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[[Category: Wang, J.]]
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[[Category: Wang, J]]
[[Category: Caspase]]
[[Category: Caspase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 07:38, 21 December 2014

Crystal Structure of drICE

3sir, resolution 2.68Å

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