4bq9
From Proteopedia
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| - | + | ==Crystal structure of the FN5 and FN6 domains of NEO1, form 1== | |
| - | + | <StructureSection load='4bq9' size='340' side='right' caption='[[4bq9]], [[Resolution|resolution]] 2.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4bq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQ9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bq6|4bq6]], [[4bq7|4bq7]], [[4bq8|4bq8]], [[4bqb|4bqb]], [[4bqc|4bqc]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bq9 RCSB], [http://www.ebi.ac.uk/pdbsum/4bq9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Repulsive guidance molecule family members (RGMs) control fundamental and diverse cellular processes including motility and adhesion, immune cell regulation and systemic iron metabolism. However, it is not known how RGMs initiate signaling through their common cell surface receptor, neogenin (NEO1). Here, we present crystal structures of the NEO1 RGM-binding region and its complex with human RGMB (also called Dragon). The RGMB structure reveals a novel protein fold, a functionally important autocatalytic cleavage mechanism and provides a framework to explain numerous disease-linked mutations in RGMs. In the complex, two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors, in a pH-dependent manner. We demonstrate that all RGM-NEO1 complexes share this architecture, which therefore represents the core of multiple signaling pathways. | ||
| - | + | Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub.,Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJ, Aricescu AR, Pasterkamp RJ, Siebold C Science. 2013 Jun 6. PMID:23744777<ref>PMID:23744777</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Aricescu, A R | + | [[Category: Aricescu, A R]] |
| - | [[Category: Bell, C H | + | [[Category: Bell, C H]] |
| - | [[Category: Bishop, B | + | [[Category: Bishop, B]] |
| - | [[Category: Erp, S van | + | [[Category: Erp, S van]] |
| - | [[Category: Gilbert, R J.C | + | [[Category: Gilbert, R J.C]] |
| - | [[Category: Healey, E | + | [[Category: Healey, E]] |
| - | [[Category: Pasterkamp, R J | + | [[Category: Pasterkamp, R J]] |
| - | [[Category: Siebold, C | + | [[Category: Siebold, C]] |
| - | [[Category: Tang, C | + | [[Category: Tang, C]] |
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
Revision as of 08:46, 21 December 2014
Crystal structure of the FN5 and FN6 domains of NEO1, form 1
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