4c53
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal Structure of Guanarito virus GP2 in the post-fusion conformation== | |
| - | + | <StructureSection load='4c53' size='340' side='right' caption='[[4c53]], [[Resolution|resolution]] 4.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4c53]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gtov Gtov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C53 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c53 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c53 RCSB], [http://www.ebi.ac.uk/pdbsum/4c53 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1 A-resolution, in the post-fusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class-I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion. | ||
| - | + | Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation.,Parsy ML, Harlos K, Huiskonen JT, Bowden TA J Virol. 2013 Sep 18. PMID:24049182<ref>PMID:24049182</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gtov]] | [[Category: Gtov]] | ||
| - | [[Category: Bowden, T A | + | [[Category: Bowden, T A]] |
| - | [[Category: Harlos, K | + | [[Category: Harlos, K]] |
| - | [[Category: Huiskonen, J T | + | [[Category: Huiskonen, J T]] |
| - | [[Category: Parsy, M | + | [[Category: Parsy, M]] |
[[Category: Arenavirus]] | [[Category: Arenavirus]] | ||
[[Category: Fusion glycoprotein]] | [[Category: Fusion glycoprotein]] | ||
Revision as of 08:54, 21 December 2014
Crystal Structure of Guanarito virus GP2 in the post-fusion conformation
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