4bnc
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the DNA-binding domain of human ETV1 complexed with DNA== | |
| - | + | <StructureSection load='4bnc' size='340' side='right' caption='[[4bnc]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[4bnc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4b06 4b06]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BNC FirstGlance]. <br> |
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bnc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bnc RCSB], [http://www.ebi.ac.uk/pdbsum/4bnc PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Ewing sarcoma. Ewing sarcoma (ES) [MIM:[http://omim.org/entry/612219 612219]]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. | [[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Ewing sarcoma. Ewing sarcoma (ES) [MIM:[http://omim.org/entry/612219 612219]]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. | ||
| - | + | == Function == | |
| - | ==Function== | + | |
[[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. | [[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Allerston, C K | + | [[Category: Allerston, C K]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Chaikuad, A | + | [[Category: Chaikuad, A]] |
| - | [[Category: Cooper, C D.O | + | [[Category: Cooper, C D.O]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Froese, D S | + | [[Category: Froese, D S]] |
| - | [[Category: Gileadi, O | + | [[Category: Gileadi, O]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Vollmar, M | + | [[Category: Vollmar, M]] |
[[Category: Dna-binding protein]] | [[Category: Dna-binding protein]] | ||
Revision as of 08:55, 21 December 2014
Crystal structure of the DNA-binding domain of human ETV1 complexed with DNA
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