4ang

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{{STRUCTURE_4ang| PDB=4ang | SCENE= }}
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==Small RNA phage PRR1 in complex with an RNA operator fragment==
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===Small RNA phage PRR1 in complex with an RNA operator fragment===
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<StructureSection load='4ang' size='340' side='right' caption='[[4ang]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23519411}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ang]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_prr1 Pseudomonas phage prr1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ANG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vf9|2vf9]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ang FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ang OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ang RCSB], [http://www.ebi.ac.uk/pdbsum/4ang PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In small RNA bacteriophages, the genomic RNA binds to the coat proteins when the viral capsid assembles. This is achieved through sequence-specific interactions between a coat-protein dimer and an RNA stem-loop that includes the start codon for the replicase gene. The structure of virus-like particles of the small RNA phage PRR1 bound to an RNA segment corresponding to this stem-loop has been solved and the binding was compared with the related, and better investigated, phage MS2. The overall conformation of the RNA is found to be similar and the residues that are involved in RNA binding in PRR1 are the same as in MS2. The arrangement of the nucleotide bases in the loop of the stem-loop is different, leading to a difference in the stacking at the conserved Tyr86, which is equivalent to Tyr85 in MS2.
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==Function==
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PRR1 coat protein binding to its RNA translational operator.,Persson M, Tars K, Liljas L Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):367-72. doi:, 10.1107/S0907444912047464. Epub 2013 Feb 16. PMID:23519411<ref>PMID:23519411</ref>
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[[http://www.uniprot.org/uniprot/COAT_BPPRR COAT_BPPRR]] Forms the phage shell; binds to the phage RNA.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4ang]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_prr1 Pseudomonas phage prr1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANG OCA].
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Pseudomonas phage prr1]]
[[Category: Pseudomonas phage prr1]]
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[[Category: Liljas, L.]]
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[[Category: Liljas, L]]
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[[Category: Persson, M.]]
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[[Category: Persson, M]]
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[[Category: Tars, K.]]
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[[Category: Tars, K]]
[[Category: Capsid]]
[[Category: Capsid]]
[[Category: Capsid protein]]
[[Category: Capsid protein]]

Revision as of 09:12, 21 December 2014

Small RNA phage PRR1 in complex with an RNA operator fragment

4ang, resolution 3.50Å

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