4b8v
From Proteopedia
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| - | + | ==Cladosporium fulvum LysM effector Ecp6 in complex with a beta-1,4- linked N-acetyl-D-glucosamine tetramer== | |
| - | + | <StructureSection load='4b8v' size='340' side='right' caption='[[4b8v]], [[Resolution|resolution]] 1.59Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4b8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Passalora_fulva Passalora fulva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8V FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b9h|4b9h]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b8v RCSB], [http://www.ebi.ac.uk/pdbsum/4b8v PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | While host immune receptors detect pathogen-associated molecular patterns to activate immunity, pathogens attempt to deregulate host immunity through secreted effectors. Fungi employ LysM effectors to prevent recognition of cell wall-derived chitin by host immune receptors, although the mechanism to compete for chitin binding remained unclear. Structural analysis of the LysM effector Ecp6 of the fungal tomato pathogen Cladosporium fulvum reveals a novel mechanism for chitin binding, mediated by intrachain LysM dimerization, leading to a chitin-binding groove that is deeply buried in the effector protein. This composite binding site involves two of the three LysMs of Ecp6 and mediates chitin binding with ultra-high (pM) affinity. Intriguingly, the remaining singular LysM domain of Ecp6 binds chitin with low micromolar affinity but can nevertheless still perturb chitin-triggered immunity. Conceivably, the perturbation by this LysM domain is not established through chitin sequestration but possibly through interference with the host immune receptor complex. DOI:http://dx.doi.org/10.7554/eLife.00790.001. | ||
| - | + | Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization.,Sanchez-Vallet A, Saleem-Batcha R, Kombrink A, Hansen G, Valkenburg DJ, Thomma BP, Mesters JR Elife. 2013 Jul 2;2:e00790. doi: 10.7554/eLife.00790. Print 2013. PMID:23840930<ref>PMID:23840930</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Passalora fulva]] | [[Category: Passalora fulva]] | ||
| - | [[Category: Hansen, G | + | [[Category: Hansen, G]] |
| - | [[Category: Mesters, J R | + | [[Category: Mesters, J R]] |
| - | [[Category: Saleem-Batcha, R | + | [[Category: Saleem-Batcha, R]] |
| - | [[Category: Sanchez-Vallet, A | + | [[Category: Sanchez-Vallet, A]] |
| - | [[Category: Thomma, B P.H J | + | [[Category: Thomma, B P.H J]] |
[[Category: Chitin]] | [[Category: Chitin]] | ||
[[Category: Lysm]] | [[Category: Lysm]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 09:19, 21 December 2014
Cladosporium fulvum LysM effector Ecp6 in complex with a beta-1,4- linked N-acetyl-D-glucosamine tetramer
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