1rju
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1rju.gif|left|200px]] | + | [[Image:1rju.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of a truncated form of yeast copper thionein''' | + | {{Structure |
| + | |PDB= 1rju |SIZE=350|CAPTION= <scene name='initialview01'>1rju</scene>, resolution 1.44Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CU1:COPPER (I) ION'>CU1</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of a truncated form of yeast copper thionein''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1RJU is a [ | + | 1RJU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJU OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of yeast copper thionein: the solution of a long-lasting enigma., Calderone V, Dolderer B, Hartmann HJ, Echner H, Luchinat C, Del Bianco C, Mangani S, Weser U, Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):51-6. Epub 2004 Dec 21. PMID:[http:// | + | The crystal structure of yeast copper thionein: the solution of a long-lasting enigma., Calderone V, Dolderer B, Hartmann HJ, Echner H, Luchinat C, Del Bianco C, Mangani S, Weser U, Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):51-6. Epub 2004 Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15613489 15613489] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bianco, C Del.]] | [[Category: Bianco, C Del.]] | ||
| Line 21: | Line 30: | ||
[[Category: Weser, U.]] | [[Category: Weser, U.]] | ||
[[Category: CU1]] | [[Category: CU1]] | ||
| - | [[Category: cu(i) metallothionein | + | [[Category: cu(i) metallothionein fragment]] |
[[Category: cu(i)-thiolate]] | [[Category: cu(i)-thiolate]] | ||
[[Category: yeast cu(i) metallothionein]] | [[Category: yeast cu(i) metallothionein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:52:38 2008'' |
Revision as of 11:52, 20 March 2008
| |||||||
| , resolution 1.44Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a truncated form of yeast copper thionein
Overview
We report here the crystal structure of yeast copper thionein (Cu-MT), determined at 1.44-A resolution. The Cu-MT structure shows the largest known oligonuclear Cu(I) thiolate cluster in biology, consisting of six trigonally and two digonally coordinated Cu(I) ions. This is at variance with the results from previous spectroscopic determinations, which were performed on MT samples containing seven rather than eight metal ions. The protein backbone has a random coil structure with the loops enfolding the copper cluster, which is located in a cleft where it is bound to 10 cysteine residues. The protein structure is somewhat different from that of Ag(7)-MT and similar, but not identical, to that of Cu(7)-MT. Besides the different structure of the metal cluster, the main differences lie in the cysteine topology and in the conformation of some portions of the backbone. The present structure suggests that Cu-MT, in addition to its role as a safe depository for copper ions in the cell, may play an active role in the delivery of copper to metal-free chaperones.
About this Structure
1RJU is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The crystal structure of yeast copper thionein: the solution of a long-lasting enigma., Calderone V, Dolderer B, Hartmann HJ, Echner H, Luchinat C, Del Bianco C, Mangani S, Weser U, Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):51-6. Epub 2004 Dec 21. PMID:15613489
Page seeded by OCA on Thu Mar 20 13:52:38 2008
