3zko
From Proteopedia
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| - | + | ==The structure of ''breathing'' dengue virus.== | |
| - | === | + | <StructureSection load='3zko' size='340' side='right' caption='[[3zko]], [[Resolution|resolution]] 13.70Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3zko]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZKO FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zko OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zko RCSB], [http://www.ebi.ac.uk/pdbsum/3zko PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Previous binding studies of antibodies that recognized partially or fully hidden epitope suggest that insect cells derived dengue virus undergoes structural changes at elevated temperature. This is confirmed by our cryo-electron microscopy images of dengue virus incubated at 37 degrees C, where viruses change their surface from smooth to rough. Here we present the cryo-electron microscopy structures of dengue virus at 37 degrees C. Image analysis showed four classes of particles. The 3D map of one of these classes, representing half of the imaged virus population, shows that the E protein shell has expanded and there is a hole at the 3-fold vertices. Fitting E protein structures into the map suggests that all the inter-dimeric and some intra-dimeric E protein interactions are weakened. The accessibility of some previously found cryptic epitopes on this class of particles is discussed. | ||
| - | + | Structural changes of dengue virus when exposed to 37{degrees}C.,Fibriansah G, Ng TS, Kostyuchenko VA, Lee J, Lee S, Wang J, Lok SM J Virol. 2013 May 1. PMID:23637405<ref>PMID:23637405</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Dengue virus 2]] | [[Category: Dengue virus 2]] | ||
| - | [[Category: Fibriansah, G | + | [[Category: Fibriansah, G]] |
| - | [[Category: Kostyuchenko, V A | + | [[Category: Kostyuchenko, V A]] |
| - | [[Category: Lee, S | + | [[Category: Lee, S]] |
| - | [[Category: Lok, S M | + | [[Category: Lok, S M]] |
| - | [[Category: Ng, T S | + | [[Category: Ng, T S]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J]] |
[[Category: Breathing structure]] | [[Category: Breathing structure]] | ||
[[Category: Dynamic structure]] | [[Category: Dynamic structure]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
Revision as of 09:22, 21 December 2014
The structure of breathing dengue virus.
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