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4bb9

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{{STRUCTURE_4bb9| PDB=4bb9 | SCENE= }}
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==Crystal structure of glucokinase regulatory protein complexed to fructose-1-phosphate==
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===Crystal structure of glucokinase regulatory protein complexed to fructose-1-phosphate===
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<StructureSection load='4bb9' size='340' side='right' caption='[[4bb9]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23621087}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bb9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BB9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=F1P:1-O-PHOSPHONO-BETA-D-FRUCTOPYRANOSE'>F1P</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bba|4bba]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bb9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4bb9 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glucokinase (GK) plays a major role in the regulation of blood glucose homeostasis in both the liver and the pancreas. In the liver, GK is controlled by the GK regulatory protein (GKRP). GKRP in turn is activated by fructose 6-phosphate (F6P) and inactivated by fructose 1-phosphate (F1P). Disrupting the GK-GKRP complex increases the activity of GK in the cytosol and is considered an attractive concept for the regulation of blood glucose. We have determined the crystal structure of GKRP in its inactive F1P-bound form. The binding site for F1P is located deeply buried at a domain interface, and H-D exchange experiments confirmed that F1P and F6P compete for this site. The structure of the inactive GKRP-F1P complex provides a starting point for understanding the mechanism of fructose phosphate-dependent GK regulation at an atomic level.
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==Function==
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Crystal Structure of Glucokinase Regulatory Protein.,Pautsch A, Stadler N, Lohle A, Rist W, Berg A, Glocker L, Nar H, Reinert D, Lenter M, Heckel A, Schnapp G, Kauschke SG Biochemistry. 2013 May 9. PMID:23621087<ref>PMID:23621087</ref>
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[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4bb9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BB9 OCA].
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</div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:023621087</ref><references group="xtra"/><references/>
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*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Berg, A.]]
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[[Category: Berg, A]]
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[[Category: Glocker, L.]]
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[[Category: Glocker, L]]
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[[Category: Heckel, A.]]
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[[Category: Heckel, A]]
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[[Category: Kauschke, S G.]]
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[[Category: Kauschke, S G]]
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[[Category: Lenter, M.]]
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[[Category: Lenter, M]]
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[[Category: Loehle, A.]]
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[[Category: Loehle, A]]
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[[Category: Nar, H.]]
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[[Category: Nar, H]]
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[[Category: Pautsch, A.]]
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[[Category: Pautsch, A]]
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[[Category: Reinert, D.]]
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[[Category: Reinert, D]]
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[[Category: Rist, W.]]
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[[Category: Rist, W]]
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[[Category: Schnapp, G.]]
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[[Category: Schnapp, G]]
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[[Category: Stadler, N.]]
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[[Category: Stadler, N]]
[[Category: Glucose metabolism]]
[[Category: Glucose metabolism]]
[[Category: Protein-binding protein]]
[[Category: Protein-binding protein]]

Revision as of 09:23, 21 December 2014

Crystal structure of glucokinase regulatory protein complexed to fructose-1-phosphate

4bb9, resolution 1.47Å

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