4bxw

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{{STRUCTURE_4bxw| PDB=4bxw | SCENE= }}
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==Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis==
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===Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis===
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<StructureSection load='4bxw' size='340' side='right' caption='[[4bxw]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23869089}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bxw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudonaja_textilis Pseudonaja textilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BXW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bxs|4bxs]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bxw RCSB], [http://www.ebi.ac.uk/pdbsum/4bxw PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The prothrombinase complex, composed of the protease factor (f)Xa and cofactor fVa, efficiently converts prothrombin to thrombin by specific, sequential cleavage at two sites. How the complex assembles and its mechanism of prothrombin processing is of central importance to human health and disease, since insufficient thrombin generation is the root-cause of hemophilia and excessive thrombin production results in thrombosis. Efforts to determine the crystal structure of the prothrombinase complex have been thwarted by the dependence of complex formation on phospholipid membrane association. Pseutarin C is an intrinsically stable prothrombinase complex preassembled in the venom gland of the Australian Eastern Brown Snake (Pseudonaja textilis). Here we report the crystal structures of the fX-fV complex and of activated fXa from P. textilis venom, and the derived model of active Pseutarin C. Structural analysis supports a single substrate binding channel on fVa, to which prothrombin and the intermediate meizothrombin bind in two different orientations, providing insight into the architecture and mechanism of the prothrombinase complex- the molecular engine of blood coagulation.
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==About this Structure==
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Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis.,Lechtenberg BC, Murray-Rust TA, Johnson DJ, Adams TE, Krishnaswamy S, Camire RM, Huntington JA Blood. 2013 Jul 18. PMID:23869089<ref>PMID:23869089</ref>
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[[4bxw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudonaja_textilis Pseudonaja textilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BXW OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Factor Xa|Factor Xa]]
*[[Factor Xa|Factor Xa]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023869089</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Pseudonaja textilis]]
[[Category: Pseudonaja textilis]]
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[[Category: Adams, T E.]]
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[[Category: Adams, T E]]
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[[Category: Camire, R M.]]
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[[Category: Camire, R M]]
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[[Category: Huntington, J A.]]
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[[Category: Huntington, J A]]
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[[Category: Johnson, D J.D.]]
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[[Category: Johnson, D J.D]]
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[[Category: Krishnaswamy, S.]]
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[[Category: Krishnaswamy, S]]
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[[Category: Lechtenberg, B C.]]
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[[Category: Lechtenberg, B C]]
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[[Category: Murray-Rust, T A.]]
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[[Category: Murray-Rust, T A]]
[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]

Revision as of 09:25, 21 December 2014

Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis

4bxw, resolution 2.71Å

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