3zm9
From Proteopedia
(Difference between revisions)
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| - | + | ==The mechanism of allosteric coupling in choline kinase a1 revealed by a rationally designed inhibitor== | |
| - | + | <StructureSection load='3zm9' size='340' side='right' caption='[[3zm9]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3zm9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZM9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QMQ:1-(4-(4-(4-((6-AMINO-9H-PURIN-9-YL)METHYL)PHENYL)BUTYL)BENZYL)-4-+(DIMETHYLAMINO)PYRIDINIUM'>QMQ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zm9 RCSB], [http://www.ebi.ac.uk/pdbsum/3zm9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Applying a CHOK hold: Combined experimental and computational studies of the binding mode of a rationally designed inhibitor of the dimeric choline kinase alpha1 (CHOKalpha1) explain the molecular mechanism of negative cooperativity and how the monomers are connected. The results give insight into how the symmetry of the dimer can be partially conserved despite a lack of conservation in the static crystal structures. | ||
| - | + | The Mechanism of Allosteric Coupling in Choline Kinase alpha1 Revealed by the Action of a Rationally Designed Inhibitor.,Sahun-Roncero M, Rubio-Ruiz B, Saladino G, Conejo-Garcia A, Espinosa A, Velazquez-Campoy A, Gervasio FL, Entrena A, Hurtado-Guerrero R Angew Chem Int Ed Engl. 2013 Feb 25. doi: 10.1002/anie.201209660. PMID:23441033<ref>PMID:23441033</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | <references | + | *[[Choline kinase|Choline kinase]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Conejo-Garcia, A | + | [[Category: Conejo-Garcia, A]] |
| - | [[Category: Entrena, A | + | [[Category: Entrena, A]] |
| - | [[Category: Espinosa, A | + | [[Category: Espinosa, A]] |
| - | [[Category: Gervasio, F L | + | [[Category: Gervasio, F L]] |
| - | [[Category: Hurtado-Guerrero, R | + | [[Category: Hurtado-Guerrero, R]] |
| - | [[Category: Rubio-Ruiz, B | + | [[Category: Rubio-Ruiz, B]] |
| - | [[Category: Sahun-Roncero, M | + | [[Category: Sahun-Roncero, M]] |
| - | [[Category: Saladino, G | + | [[Category: Saladino, G]] |
| - | [[Category: Velazquez-Campoy, A | + | [[Category: Velazquez-Campoy, A]] |
[[Category: Allosteric mechanism]] | [[Category: Allosteric mechanism]] | ||
[[Category: Elastic network analysis]] | [[Category: Elastic network analysis]] | ||
[[Category: Negative cooperativity]] | [[Category: Negative cooperativity]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 09:44, 21 December 2014
The mechanism of allosteric coupling in choline kinase a1 revealed by a rationally designed inhibitor
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