3zgx

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{{STRUCTURE_3zgx| PDB=3zgx | SCENE= }}
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==Crystal structure of the kleisin-N SMC interface in prokaryotic condensin==
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===Crystal structure of the kleisin-N SMC interface in prokaryotic condensin===
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<StructureSection load='3zgx' size='340' side='right' caption='[[3zgx]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23353789}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zgx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGX FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zgx RCSB], [http://www.ebi.ac.uk/pdbsum/3zgx PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Eukaryotic structural maintenance of chromosomes (SMC)-kleisin complexes form large, ring-shaped assemblies that promote accurate chromosome segregation. Their asymmetric structural core comprises SMC heterodimers that associate with both ends of a kleisin subunit. However, prokaryotic condensin Smc-ScpAB is composed of symmetric Smc homodimers associated with the kleisin ScpA in a postulated symmetrical manner. Here, we demonstrate that Smc molecules have two distinct binding sites for ScpA. The N terminus of ScpA binds the Smc coiled coil, whereas the C terminus binds the Smc ATPase domain. We show that in Bacillus subtilis cells, an Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complexes. We define a molecular mechanism that ensures asymmetric assembly, and we conclude that the basic architecture of SMC-kleisin rings evolved before the emergence of eukaryotes.
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==Function==
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An asymmetric SMC-kleisin bridge in prokaryotic condensin.,Burmann F, Shin HC, Basquin J, Soh YM, Gimenez-Oya V, Kim YG, Oh BH, Gruber S Nat Struct Mol Biol. 2013 Jan 27;20(3):371-9. doi: 10.1038/nsmb.2488. Epub 2013, Jan 27. PMID:23353789<ref>PMID:23353789</ref>
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[[http://www.uniprot.org/uniprot/SMC_BACSU SMC_BACSU]] Required for chromosome condensation and partitioning.<ref>PMID:9573042</ref><ref>PMID:9701812</ref> [[http://www.uniprot.org/uniprot/SCPA_BACSU SCPA_BACSU]] Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.[HAMAP-Rule:MF_01805]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3zgx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGX OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Basquin, J.]]
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[[Category: Basquin, J]]
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[[Category: Burmann, F.]]
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[[Category: Burmann, F]]
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[[Category: Gimenez, V.]]
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[[Category: Gimenez, V]]
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[[Category: Gruber, S.]]
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[[Category: Gruber, S]]
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[[Category: Kim, Y.]]
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[[Category: Kim, Y]]
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[[Category: Oh, B.]]
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[[Category: Oh, B]]
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[[Category: Shin, H.]]
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[[Category: Shin, H]]
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[[Category: Soh, Y.]]
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[[Category: Soh, Y]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]

Revision as of 09:59, 21 December 2014

Crystal structure of the kleisin-N SMC interface in prokaryotic condensin

3zgx, resolution 3.40Å

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