This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3zgx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_3zgx| PDB=3zgx | SCENE= }}
+
==Crystal structure of the kleisin-N SMC interface in prokaryotic condensin==
-
===Crystal structure of the kleisin-N SMC interface in prokaryotic condensin===
+
<StructureSection load='3zgx' size='340' side='right' caption='[[3zgx]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_23353789}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3zgx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZGX FirstGlance]. <br>
 +
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zgx RCSB], [http://www.ebi.ac.uk/pdbsum/3zgx PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Eukaryotic structural maintenance of chromosomes (SMC)-kleisin complexes form large, ring-shaped assemblies that promote accurate chromosome segregation. Their asymmetric structural core comprises SMC heterodimers that associate with both ends of a kleisin subunit. However, prokaryotic condensin Smc-ScpAB is composed of symmetric Smc homodimers associated with the kleisin ScpA in a postulated symmetrical manner. Here, we demonstrate that Smc molecules have two distinct binding sites for ScpA. The N terminus of ScpA binds the Smc coiled coil, whereas the C terminus binds the Smc ATPase domain. We show that in Bacillus subtilis cells, an Smc dimer is bridged by a single ScpAB to generate asymmetric tripartite rings analogous to eukaryotic SMC complexes. We define a molecular mechanism that ensures asymmetric assembly, and we conclude that the basic architecture of SMC-kleisin rings evolved before the emergence of eukaryotes.
-
==Function==
+
An asymmetric SMC-kleisin bridge in prokaryotic condensin.,Burmann F, Shin HC, Basquin J, Soh YM, Gimenez-Oya V, Kim YG, Oh BH, Gruber S Nat Struct Mol Biol. 2013 Jan 27;20(3):371-9. doi: 10.1038/nsmb.2488. Epub 2013, Jan 27. PMID:23353789<ref>PMID:23353789</ref>
-
[[http://www.uniprot.org/uniprot/SMC_BACSU SMC_BACSU]] Required for chromosome condensation and partitioning.<ref>PMID:9573042</ref><ref>PMID:9701812</ref> [[http://www.uniprot.org/uniprot/SCPA_BACSU SCPA_BACSU]] Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.[HAMAP-Rule:MF_01805]
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[3zgx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGX OCA].
+
</div>
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<references group="xtra"/><references/>
+
__TOC__
 +
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
-
[[Category: Basquin, J.]]
+
[[Category: Basquin, J]]
-
[[Category: Burmann, F.]]
+
[[Category: Burmann, F]]
-
[[Category: Gimenez, V.]]
+
[[Category: Gimenez, V]]
-
[[Category: Gruber, S.]]
+
[[Category: Gruber, S]]
-
[[Category: Kim, Y.]]
+
[[Category: Kim, Y]]
-
[[Category: Oh, B.]]
+
[[Category: Oh, B]]
-
[[Category: Shin, H.]]
+
[[Category: Shin, H]]
-
[[Category: Soh, Y.]]
+
[[Category: Soh, Y]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]

Revision as of 09:59, 21 December 2014

Crystal structure of the kleisin-N SMC interface in prokaryotic condensin

3zgx, resolution 3.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zgx"
Personal tools