4fog

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{{STRUCTURE_4fog| PDB=4fog | SCENE= }}
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==Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid==
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===Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid===
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<StructureSection load='4fog' size='340' side='right' caption='[[4fog]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fog]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FOG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qj7|3qj7]], [[4foa|4foa]], [[4fox|4fox]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT2834, MTV002.29c, Rv2764c, thyA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fog OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fog RCSB], [http://www.ebi.ac.uk/pdbsum/4fog PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
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*[[Thymidylate synthase|Thymidylate synthase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4fog]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOG OCA].
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[[Category: Mycobacterium tuberculosis h37rv]]
[[Category: Mycobacterium tuberculosis h37rv]]
[[Category: Thymidylate synthase]]
[[Category: Thymidylate synthase]]
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[[Category: Bruning, J B.]]
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[[Category: Bruning, J B]]
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[[Category: Harshbarger, W.]]
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[[Category: Harshbarger, W]]
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[[Category: Reddy, M C.M.]]
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[[Category: Reddy, M C.M]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini, J C]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
 
[[Category: Tbsgc]]
[[Category: Tbsgc]]
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[[Category: Thymidylate synthase]]
 
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 10:40, 21 December 2014

Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid

4fog, resolution 2.40Å

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