4f45

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{{STRUCTURE_4f45| PDB=4f45 | SCENE= }}
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==Crystal structure of human CD38 E226Q mutant in complex with NAADP==
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===Crystal structure of human CD38 E226Q mutant in complex with NAADP===
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<StructureSection load='4f45' size='340' side='right' caption='[[4f45]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f45]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F45 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DN4:[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>DN4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f46|4f46]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f45 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f45 RCSB], [http://www.ebi.ac.uk/pdbsum/4f45 PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4f45]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F45 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hao, Q.]]
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[[Category: Hao, Q]]
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[[Category: Lee, H C.]]
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[[Category: Lee, H C]]
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[[Category: Zhang, H.]]
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[[Category: Zhang, H]]
[[Category: Adp-ribosyl cyclase]]
[[Category: Adp-ribosyl cyclase]]
[[Category: Calcium signaling]]
[[Category: Calcium signaling]]

Revision as of 10:42, 21 December 2014

Crystal structure of human CD38 E226Q mutant in complex with NAADP

4f45, resolution 2.10Å

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