4gj4

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{{STRUCTURE_4gj4| PDB=4gj4 | SCENE= }}
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==The Crystal Structure of the soluble Guanylate Cyclase PAS alpha domain from Manduca sexta==
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===The Crystal Structure of the soluble Guanylate Cyclase PAS alpha domain from Manduca sexta===
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<StructureSection load='4gj4' size='340' side='right' caption='[[4gj4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23934793}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gj4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GJ4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gj4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gj4 RCSB], [http://www.ebi.ac.uk/pdbsum/4gj4 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Soluble guanylate cyclase (sGC) is a heterodimeric heme protein of ~150 kDa and the primary nitric oxide receptor. Binding of NO stimulates cyclase activity, leading to regulation of cardiovascular physiology and providing attractive opportunities for drug discovery. How sGC is stimulated and where candidate drugs bind remains unknown. The alpha and beta sGC chains are each composed of Heme-Nitric Oxide Oxygen (H-NOX), Per-ARNT-Sim (PAS), coiled-coil and cyclase domains. Here, we present the crystal structure of the alpha1 PAS domain to 1.8 A resolution. The structure reveals the binding surfaces of importance to heterodimer function, particularly with respect to regulating NO binding to heme in the beta1 H-NOX domain. It also reveals a small internal cavity that may serve to bind ligands or participate in signal transduction.
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==About this Structure==
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Crystal structure of the alpha subunit PAS domain from soluble guanylyl cyclase.,Purohit R, Weichsel A, Montfort WR Protein Sci. 2013 Aug 12. doi: 10.1002/pro.2331. PMID:23934793<ref>PMID:23934793</ref>
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[[4gj4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GJ4 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023934793</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Guanylate cyclase]]
[[Category: Guanylate cyclase]]
[[Category: Manduca sexta]]
[[Category: Manduca sexta]]
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[[Category: Montfort, W R.]]
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[[Category: Montfort, W R]]
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[[Category: Purohit, R.]]
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[[Category: Purohit, R]]
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[[Category: Weichsel, A.]]
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[[Category: Weichsel, A]]
[[Category: Allosteric regulation]]
[[Category: Allosteric regulation]]
[[Category: Cgmp]]
[[Category: Cgmp]]

Revision as of 10:43, 21 December 2014

The Crystal Structure of the soluble Guanylate Cyclase PAS alpha domain from Manduca sexta

4gj4, resolution 1.80Å

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