1rsf

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[[Image:1rsf.gif|left|200px]]<br /><applet load="1rsf" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1rsf.gif|left|200px]]
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caption="1rsf" />
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'''NMR Structure of Monomeric CAR d1 domain'''<br />
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{{Structure
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|PDB= 1rsf |SIZE=350|CAPTION= <scene name='initialview01'>1rsf</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= CXADR, CAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''NMR Structure of Monomeric CAR d1 domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1RSF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSF OCA].
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1RSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSF OCA].
==Reference==
==Reference==
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Solution structure of the coxsackievirus and adenovirus receptor domain 1., Jiang S, Jacobs A, Laue TM, Caffrey M, Biochemistry. 2004 Feb 24;43(7):1847-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14967025 14967025]
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Solution structure of the coxsackievirus and adenovirus receptor domain 1., Jiang S, Jacobs A, Laue TM, Caffrey M, Biochemistry. 2004 Feb 24;43(7):1847-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14967025 14967025]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: nmr]]
[[Category: nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:54:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:55:38 2008''

Revision as of 11:55, 20 March 2008

Image:1rsf.gif


PDB ID 1rsf

Drag the structure with the mouse to rotate
Gene: CXADR, CAR (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



NMR Structure of Monomeric CAR d1 domain


Contents

Overview

The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus B (CVB) and adenovirus (Ad). The normal cellular function of CAR, which is expressed in a wide variety of tissue types, is thought to involve homophilic cell adhesion in the developing brain. The extracellular domain of CAR consists of two immunoglobulin (Ig) domains termed CAR-D1 and CAR-D2. CAR-D1 is shown by sedimentation velocity to be monomeric at pH 3.0. The solution structure and the dynamic properties of monomeric CAR-D1 have been determined by NMR spectroscopy at pH 3.0. The determinants of the CAR-D1 monomer-dimer equilibrium, as well as the binding site of CVB and Ad on CAR, are discussed in light of the monomer structure.

Disease

Known diseases associated with this structure: Adrenocortical tumor, somatic OMIM:[188830], Carney complex, type 1 OMIM:[188830], Myxoma, intracardiac OMIM:[188830], Pigmented adrenocortical disease, primary, 1 OMIM:[188830], Spastic paraplegia-7 OMIM:[602783], Thyroid carcinoma, papillary OMIM:[188830]

About this Structure

1RSF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the coxsackievirus and adenovirus receptor domain 1., Jiang S, Jacobs A, Laue TM, Caffrey M, Biochemistry. 2004 Feb 24;43(7):1847-53. PMID:14967025

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