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4fzs

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{{STRUCTURE_4fzs| PDB=4fzs | SCENE= }}
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==Structure of human SNX1 BAR domain==
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===Structure of human SNX1 BAR domain===
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<StructureSection load='4fzs' size='340' side='right' caption='[[4fzs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fzs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FZS FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fzs RCSB], [http://www.ebi.ac.uk/pdbsum/4fzs PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN]] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref>
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*[[Sorting nexin|Sorting nexin]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4fzs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZS OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bhatia, V K.]]
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[[Category: Bhatia, V K]]
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[[Category: Cullen, P J.]]
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[[Category: Cullen, P J]]
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[[Category: Hurley, J H.]]
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[[Category: Hurley, J H]]
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[[Category: Kloer, D P.]]
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[[Category: Kloer, D P]]
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[[Category: Sessions, R B.]]
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[[Category: Sessions, R B]]
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[[Category: Stamou, D.]]
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[[Category: Stamou, D]]
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[[Category: Traer, C J.]]
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[[Category: Traer, C J]]
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[[Category: Weering, J R.T van.]]
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[[Category: Weering, J R.T van]]
[[Category: Bar]]
[[Category: Bar]]
[[Category: Membrane remodeling]]
[[Category: Membrane remodeling]]
[[Category: Protein transport]]
[[Category: Protein transport]]

Revision as of 10:53, 21 December 2014

Structure of human SNX1 BAR domain

4fzs, resolution 2.80Å

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