This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate== | |
| - | + | <StructureSection load='4ein' size='340' side='right' caption='[[4ein]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ein]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EIN FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOH:2-DEOXY-N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NOH</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tyms ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ein OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ein RCSB], [http://www.ebi.ac.uk/pdbsum/4ein PDBsum]</span></td></tr> | ||
| + | </table> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Thymidylate synthase|Thymidylate synthase]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Thymidylate synthase]] | [[Category: Thymidylate synthase]] | ||
| - | [[Category: Dowiercial, A | + | [[Category: Dowiercial, A]] |
| - | [[Category: Jarmula, A | + | [[Category: Jarmula, A]] |
| - | [[Category: Kierdaszuk, B | + | [[Category: Kierdaszuk, B]] |
| - | [[Category: Rode, W | + | [[Category: Rode, W]] |
| - | [[Category: Rypniewski, W R | + | [[Category: Rypniewski, W R]] |
| - | [[Category: Wilk, P | + | [[Category: Wilk, P]] |
[[Category: Binding site]] | [[Category: Binding site]] | ||
[[Category: Catalysis]] | [[Category: Catalysis]] | ||
Revision as of 10:54, 21 December 2014
Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate
| |||||||||||
