4gzk
From Proteopedia
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| - | + | ==Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12== | |
| - | + | <StructureSection load='4gzk' size='340' side='right' caption='[[4gzk]], [[Resolution|resolution]] 1.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4gzk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_phi12 Pseudomonas phage phi12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZK FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=161736 Pseudomonas phage phi12])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gzk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gzk RCSB], [http://www.ebi.ac.uk/pdbsum/4gzk PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We have determined the structure of P2, the self-priming RdRp from cystovirus varphi12 in two crystal forms (A, B) at resolutions of 1.7 A and 2.1 A. Form A contains Mg(2+) bound at a site that deviates from the canonical noncatalytic position seen in form B. These structures provide insight into the temperature sensitivity of a ts-mutant. However, the tunnel through which template ssRNA accesses the active site is partially occluded by a flexible loop; this feature, along with suboptimal positioning of other structural elements that prevent the formation of a stable initiation complex, indicate an inactive conformation in crystallo. Proteins 2013; 81:1479-1484. (c) 2013 Wiley Periodicals, Inc. | ||
| - | + | Structure of the RNA-directed RNA Polymerase from the cystovirus varphi12.,Ren Z, C Franklin M, Ghose R Proteins. 2013 Aug;81(8):1479-84. doi: 10.1002/prot.24297. Epub 2013 Jun 1. PMID:23568335<ref>PMID:23568335</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | |||
| + | ==See Also== | ||
| + | *[[RNA polymerase|RNA polymerase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Pseudomonas phage phi12]] | [[Category: Pseudomonas phage phi12]] | ||
| - | [[Category: Franklin, M | + | [[Category: Franklin, M]] |
| - | [[Category: Ghose, R | + | [[Category: Ghose, R]] |
| - | [[Category: Ren, Z | + | [[Category: Ren, Z]] |
[[Category: Rna-directed rna polymerase]] | [[Category: Rna-directed rna polymerase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 10:57, 21 December 2014
Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12
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