4gxl

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{{STRUCTURE_4gxl| PDB=4gxl | SCENE= }}
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==The crystal structure of Galectin-8 C-CRD in complex with NDP52==
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===The crystal structure of Galectin-8 C-CRD in complex with NDP52===
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<StructureSection load='4gxl' size='340' side='right' caption='[[4gxl]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23386746}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GXL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gxl RCSB], [http://www.ebi.ac.uk/pdbsum/4gxl PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Autophagy, the process of lysosome-dependent degradation of cytosolic components, is a mechanism by which cells selectively engulf invading pathogens to protect themselves against infection. Galectin-8, a cytosolic protein with specificity for beta-galactoside-containing glycans, binds endosomal and lysosomal membranes that have been damaged, for example, by pathogens, and selectively recruits the autophagy cargo receptor NDP52 to induce autophagy. We solved the crystal structure of the NDP52-galectin-8 complex to show how NDP52 exclusively binds galectin-8 and, consequently, why other galectins do not restrict the growth of Salmonella in human cells.
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==Function==
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Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy.,Li S, Wandel MP, Li F, Liu Z, He C, Wu J, Shi Y, Randow F Sci Signal. 2013 Feb 5;6(261):ra9. doi: 10.1126/scisignal.2003730. PMID:23386746<ref>PMID:23386746</ref>
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[[http://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref> [[http://www.uniprot.org/uniprot/CACO2_HUMAN CACO2_HUMAN]] May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.<ref>PMID:17635994</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4gxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXL OCA].
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</div>
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==Reference==
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==See Also==
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<references group="xtra"/><references/>
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*[[Galectin|Galectin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: He, C.]]
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[[Category: He, C]]
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[[Category: Li, F.]]
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[[Category: Li, F]]
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[[Category: Li, S.]]
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[[Category: Li, S]]
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[[Category: Liu, Z.]]
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[[Category: Liu, Z]]
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[[Category: Randow, F.]]
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[[Category: Randow, F]]
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[[Category: Shi, Y.]]
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[[Category: Shi, Y]]
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[[Category: Wandel, M P.]]
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[[Category: Wandel, M P]]
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[[Category: Wu, J.]]
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[[Category: Wu, J]]
[[Category: Carbohydrate recognition]]
[[Category: Carbohydrate recognition]]
[[Category: Ndp52]]
[[Category: Ndp52]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]

Revision as of 10:58, 21 December 2014

The crystal structure of Galectin-8 C-CRD in complex with NDP52

4gxl, resolution 2.02Å

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