4g8e

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{{STRUCTURE_4g8e| PDB=4g8e | SCENE= }}
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==Crystal Structure of clone18 TCR==
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===Crystal Structure of clone18 TCR===
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<StructureSection load='4g8e' size='340' side='right' caption='[[4g8e]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23727893}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G8E FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g8f|4g8f]], [[4g8g|4g8g]], [[4g8i|4g8i]], [[4g9d|4g9d]], [[4g9f|4g9f]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g8e RCSB], [http://www.ebi.ac.uk/pdbsum/4g8e PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human T cell antigen receptors (TCRs) pair in millions of combinations to create complex and unique T cell repertoires for each person. Through the use of tetramers to analyze TCRs reactive to the antigen-presenting molecule CD1b, we detected T cells with highly stereotyped TCR alpha-chains present among genetically unrelated patients with tuberculosis. The germline-encoded, mycolyl lipid-reactive (GEM) TCRs had an alpha-chain bearing the variable (V) region TRAV1-2 rearranged to the joining (J) region TRAJ9 with few nontemplated (N)-region additions. Analysis of TCRs by high-throughput sequencing, binding and crystallography showed linkage of TCRalpha sequence motifs to high-affinity recognition of antigen. Thus, the CD1-reactive TCR repertoire is composed of at least two compartments: high-affinity GEM TCRs, and more-diverse TCRs with low affinity for CD1b-lipid complexes. We found high interdonor conservation of TCRs that probably resulted from selection by a nonpolymorphic antigen-presenting molecule and an immunodominant antigen.
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==About this Structure==
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A conserved human T cell population targets mycobacterial antigens presented by CD1b.,Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, Rossjohn J, Moody DB Nat Immunol. 2013 Jun 2;14(7):706-13. doi: 10.1038/ni.2630. Epub 2013 Jun 2. PMID:23727893<ref>PMID:23727893</ref>
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[[4g8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8E OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023727893</ref><references group="xtra"/><references/>
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</div>
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==See Also==
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*[[T-cell receptor|T-cell receptor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bhati, M.]]
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[[Category: Bhati, M]]
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[[Category: Gras, S.]]
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[[Category: Gras, S]]
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[[Category: Rossjohn, J.]]
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[[Category: Rossjohn, J]]
[[Category: Cd1b]]
[[Category: Cd1b]]
[[Category: Gmm]]
[[Category: Gmm]]

Revision as of 10:58, 21 December 2014

Crystal Structure of clone18 TCR

4g8e, resolution 2.20Å

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