1rtq
From Proteopedia
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| - | [[Image:1rtq.gif|left|200px]] | + | [[Image:1rtq.gif|left|200px]] |
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| - | '''The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica''' | + | {{Structure |
| + | |PDB= 1rtq |SIZE=350|CAPTION= <scene name='initialview01'>1rtq</scene>, resolution 0.95Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Bacterial_leucyl_aminopeptidase Bacterial leucyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.10 3.4.11.10] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RTQ is a [ | + | 1RTQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_proteolyticus Vibrio proteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTQ OCA]. |
==Reference== | ==Reference== | ||
| - | The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica., Desmarais W, Bienvenue DL, Bzymek KP, Petsko GA, Ringe D, Holz RC, J Biol Inorg Chem. 2006 Jun;11(4):398-408. Epub 2006 Apr 5. PMID:[http:// | + | The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica., Desmarais W, Bienvenue DL, Bzymek KP, Petsko GA, Ringe D, Holz RC, J Biol Inorg Chem. 2006 Jun;11(4):398-408. Epub 2006 Apr 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16596389 16596389] |
[[Category: Bacterial leucyl aminopeptidase]] | [[Category: Bacterial leucyl aminopeptidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:56:05 2008'' |
Revision as of 11:56, 20 March 2008
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| , resolution 0.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Activity: | Bacterial leucyl aminopeptidase, with EC number 3.4.11.10 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica
Overview
The aminopeptidase from Aeromonas proteolytica (AAP) contains two zinc ions in the active site and catalyzes the degradation of peptides. Herein we report the crystal structures of AAP at 0.95-A resolution at neutral pH and at 1.24-A resolution at low pH. The combination of these structures allowed the precise modeling of atomic positions, the identification of the metal bridging oxygen species, and insight into the physical properties of the metal ions. On the basis of these structures, a new putative catalytic mechanism is proposed for AAP that is likely relevant to all binuclear metalloproteases.
About this Structure
1RTQ is a Single protein structure of sequence from Vibrio proteolyticus. Full crystallographic information is available from OCA.
Reference
The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica., Desmarais W, Bienvenue DL, Bzymek KP, Petsko GA, Ringe D, Holz RC, J Biol Inorg Chem. 2006 Jun;11(4):398-408. Epub 2006 Apr 5. PMID:16596389
Page seeded by OCA on Thu Mar 20 13:56:05 2008
