1rtx

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[[Image:1rtx.jpg|left|200px]]<br /><applet load="1rtx" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1rtx.jpg|left|200px]]
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caption="1rtx, resolution 1.80&Aring;" />
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'''Crystal Structure of Synechocystis Hemoglobin with a Covalent Heme Linkage'''<br />
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{{Structure
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|PDB= 1rtx |SIZE=350|CAPTION= <scene name='initialview01'>1rtx</scene>, resolution 1.80&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene> and <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene>
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|ACTIVITY=
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|GENE= GLBN, SLR2097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1143 Synechocystis sp.])
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}}
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'''Crystal Structure of Synechocystis Hemoglobin with a Covalent Heme Linkage'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1RTX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.] with <scene name='pdbligand=CD:'>CD</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTX OCA].
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1RTX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTX OCA].
==Reference==
==Reference==
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The crystal structure of Synechocystis hemoglobin with a covalent heme linkage., Hoy JA, Kundu S, Trent JT 3rd, Ramaswamy S, Hargrove MS, J Biol Chem. 2004 Apr 16;279(16):16535-42. Epub 2004 Jan 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14736872 14736872]
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The crystal structure of Synechocystis hemoglobin with a covalent heme linkage., Hoy JA, Kundu S, Trent JT 3rd, Ramaswamy S, Hargrove MS, J Biol Chem. 2004 Apr 16;279(16):16535-42. Epub 2004 Jan 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14736872 14736872]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Synechocystis sp.]]
[[Category: Synechocystis sp.]]
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[[Category: truncated]]
[[Category: truncated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:54:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:56:11 2008''

Revision as of 11:56, 20 March 2008

Image:1rtx.jpg


PDB ID 1rtx

Drag the structure with the mouse to rotate
, resolution 1.80Å
Ligands: , , and
Gene: GLBN, SLR2097 (Synechocystis sp.)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Synechocystis Hemoglobin with a Covalent Heme Linkage


Overview

The x-ray crystal structure of Synechocystis hemoglobin has been solved to a resolution of 1.8 A. The conformation of this structure is surprisingly different from that of the previously reported solution structure, probably due in part to a covalent linkage between the heme 2-vinyl and His117 that is present in the crystal structure but not in the structure solved by NMR. Synechocystis hemoglobin is a hexacoordinate hemoglobin in which the heme iron is coordinated by both the proximal and distal histidines. It is also a member of the "truncated hemoglobin" family that is much shorter in primary structure than vertebrate and plant hemoglobins. In contrast to other truncated hemoglobins, the crystal structure of Synechocystis hemoglobin displays no "ligand tunnel" and shows that several important amino acid side chains extrude into the solvent instead of residing inside the heme pocket. The stereochemistry of hexacoordination is compared with other hexacoordinate hemoglobins and cytochromes in an effort to illuminate factors contributing to ligand affinity in hexacoordinate hemoglobins.

About this Structure

1RTX is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

The crystal structure of Synechocystis hemoglobin with a covalent heme linkage., Hoy JA, Kundu S, Trent JT 3rd, Ramaswamy S, Hargrove MS, J Biol Chem. 2004 Apr 16;279(16):16535-42. Epub 2004 Jan 21. PMID:14736872

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