4gqi
From Proteopedia
(Difference between revisions)
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| - | + | ==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation== | |
| - | + | <StructureSection load='4gqi' size='340' side='right' caption='[[4gqi]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | { | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[4gqi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQI FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M49:N-{(3R)-3-[2-(ACETYLAMINO)ETHYL]-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL}ACETAMIDE'>M49</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gr9|4gr9]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gqi RCSB], [http://www.ebi.ac.uk/pdbsum/4gqi PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3. | ||
| - | + | Synthesis of novel capital EM, Cyrilliccapital TE, Cyrillic3 receptor ligands via an unusual Knoevenagel condensation.,Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS Bioorg Med Chem Lett. 2012 Dec 15;22(24):7578-81. doi:, 10.1016/j.bmcl.2012.10.005. Epub 2012 Oct 17. PMID:23131339<ref>PMID:23131339</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Quinone reductase|Quinone reductase]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Jensen, K C | + | [[Category: Jensen, K C]] |
| - | [[Category: Lozinskaya, N A | + | [[Category: Lozinskaya, N A]] |
| - | [[Category: Mesecar, A D | + | [[Category: Mesecar, A D]] |
| - | [[Category: Proskurnina, M V | + | [[Category: Proskurnina, M V]] |
| - | [[Category: Sosonyuk, S E | + | [[Category: Sosonyuk, S E]] |
| - | [[Category: Volkova, M S | + | [[Category: Volkova, M S]] |
| - | [[Category: Zefirov, N S | + | [[Category: Zefirov, N S]] |
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 11:07, 21 December 2014
Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation
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