4eeq

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{{STRUCTURE_4eeq| PDB=4eeq | SCENE= }}
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==Crystal structure of E. faecalis DNA ligase with inhibitor==
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===Crystal structure of E. faecalis DNA ligase with inhibitor===
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<StructureSection load='4eeq' size='340' side='right' caption='[[4eeq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4eeq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EEQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0OX:4-AMINO-2-(CYCLOPENTYLOXY)PYRIMIDINE-5-CARBOXAMIDE'>0OX</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4efb|4efb]], [[4efe|4efe]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ligA, EF_0722 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eeq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eeq RCSB], [http://www.ebi.ac.uk/pdbsum/4eeq PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
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*[[DNA ligase|DNA ligase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4eeq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EEQ OCA].
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[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Charifson, P.]]
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[[Category: Charifson, P]]
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[[Category: Wang, T.]]
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[[Category: Wang, T]]
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[[Category: Wei, Y.]]
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[[Category: Wei, Y]]
[[Category: Adenylation]]
[[Category: Adenylation]]
[[Category: Alfa-betta protein]]
[[Category: Alfa-betta protein]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Ligase-ligase inhibitor complex]]

Revision as of 11:14, 21 December 2014

Crystal structure of E. faecalis DNA ligase with inhibitor

4eeq, resolution 2.10Å

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