1rvf

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[[Image:1rvf.jpg|left|200px]]<br /><applet load="1rvf" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1rvf.jpg|left|200px]]
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caption="1rvf, resolution 4.0&Aring;" />
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'''FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS'''<br />
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{{Structure
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|PDB= 1rvf |SIZE=350|CAPTION= <scene name='initialview01'>1rvf</scene>, resolution 4.0&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1RVF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10], [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1RVF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVF OCA].
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1RVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10], [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1RVF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVF OCA].
==Reference==
==Reference==
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Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8848050 8848050]
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Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8848050 8848050]
[[Category: Human rhinovirus 10]]
[[Category: Human rhinovirus 10]]
[[Category: Human rhinovirus sp.]]
[[Category: Human rhinovirus sp.]]
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[[Category: thiol protease]]
[[Category: thiol protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:55:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:56:46 2008''

Revision as of 11:56, 20 March 2008

Image:1rvf.jpg


PDB ID 1rvf

Drag the structure with the mouse to rotate
, resolution 4.0Å
Coordinates: save as pdb, mmCIF, xml



FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS


Overview

The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradiction to the most commonly held model of antibody-mediated neutralization, Fab17-IA does not induce a conformational change in the HRV-14 capsid. Instead, the paratope of the antibody undergoes a large conformational change to accommodate the epitope. Unlike any previously described antibody-antigen structure, the conserved framework region of the antibody makes extensive contact with the viral surface. Fab17-IA penetrates deep within the canyon in which the cellular receptor for HRV-14 binds. Hence, it is unlikely that viral quaternary structure evolves merely to evade immune recognition. Instead, the shape and position of the receptor-binding region on a virus probably dictates receptor binding and subsequent uncoating events and has little or no influence on concealing the virus from the immune system.

About this Structure

1RVF is a Protein complex structure of sequences from Human rhinovirus 10, Human rhinovirus sp. and Mus musculus. The following page contains interesting information on the relation of 1RVF with [Poliovirus and Rhinovirus]. Full crystallographic information is available from OCA.

Reference

Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:8848050

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