4gq9
From Proteopedia
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| - | + | ==Chikungunya virus neutralizing antibody 9.8B Fab fragment== | |
| - | + | <StructureSection load='4gq9' size='340' side='right' caption='[[4gq9]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4gq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQ9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gq9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gq9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A 5.3 A resolution, cryo-electron microscopy (cryoEM) map of Chikungunya virus-like particles (VLPs) has been interpreted using the previously published crystal structure of the Chikungunya E1-E2 glycoprotein heterodimer. The heterodimer structure was divided into domains to obtain a good fit to the cryoEM density. Differences in the T = 4 quasi-equivalent heterodimer components show their adaptation to different environments. The spikes on the icosahedral 3-fold axes and those in general positions are significantly different, possibly representing different phases during initial generation of fusogenic E1 trimers. CryoEM maps of neutralizing Fab fragments complexed with VLPs have been interpreted using the crystal structures of the Fab fragments and the VLP structure. Based on these analyses the CHK-152 antibody was shown to stabilize the viral surface, hindering the exposure of the fusion-loop, likely neutralizing infection by blocking fusion. The CHK-9, m10 and m242 antibodies surround the receptor-attachment site, probably inhibiting infection by blocking cell attachment. DOI:http://dx.doi.org/10.7554/eLife.00435.001. | ||
| - | + | Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization.,Sun S, Xiang Y, Akahata W, Holdaway H, Pal P, Zhang X, Diamond MS, Nabel GJ, Rossmann MG Elife. 2013;2:e00435. doi: 10.7554/eLife.00435. Epub 2013 Apr 2. PMID:23577234<ref>PMID:23577234</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | |||
| + | ==See Also== | ||
| + | *[[Antibody|Antibody]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
[[Category: Sun, S]] | [[Category: Sun, S]] | ||
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Igg fold]] | [[Category: Igg fold]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 11:42, 21 December 2014
Chikungunya virus neutralizing antibody 9.8B Fab fragment
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