4hk1
From Proteopedia
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| - | + | ==Crystal Structure of PCNA from Drosophila melanogaster== | |
| - | === | + | <StructureSection load='4hk1' size='340' side='right' caption='[[4hk1]], [[Resolution|resolution]] 2.00Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4hk1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HK1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mus209, PCNA, CG9193 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hk1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hk1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hk1 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Proliferating cell nuclear antigen (PCNA) plays essential roles in DNA replication, DNA repair, cell-cycle regulation and chromatin metabolism. The PCNA from Drosophila melanogaster (DmPCNA) was purified and crystallized. The crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A. The structure of DmPCNA was determined by molecular replacement. DmPCNA forms a symmetric homotrimer in a head-to-tail manner. An interdomain connector loop (IDCL) links the N- and C-terminal domains. Additionally, the N-terminal and C-terminal domains contact each other through hydrophobic associations. Compared with human PCNA, the IDCL of DmPCNA has conformational changes, which may explain their difference in function. This work provides a structural basis for further functional and evolutionary studies of PCNA. | ||
| - | + | Structure of PCNA from Drosophila melanogaster.,Wang K, Shi Z, Zhang M, Cheng D Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):387-92., doi: 10.1107/S1744309113004971. Epub 2013 Mar 28. PMID:23545643<ref>PMID:23545643</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | [[ | + | </div> |
| + | |||
| + | ==See Also== | ||
| + | *[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Shi, Z B | + | [[Category: Shi, Z B]] |
| - | [[Category: Wang, K | + | [[Category: Wang, K]] |
| - | [[Category: Zhou, Z C | + | [[Category: Zhou, Z C]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cell cycle control]] | [[Category: Cell cycle control]] | ||
Revision as of 12:05, 21 December 2014
Crystal Structure of PCNA from Drosophila melanogaster
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