1s1e

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[[Image:1s1e.gif|left|200px]]<br /><applet load="1s1e" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1s1e.gif|left|200px]]
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caption="1s1e, resolution 2.3&Aring;" />
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'''Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)'''<br />
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{{Structure
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|PDB= 1s1e |SIZE=350|CAPTION= <scene name='initialview01'>1s1e</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE= KCNIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1S1E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1E OCA].
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1S1E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1E OCA].
==Reference==
==Reference==
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Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1., Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lu Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ, Neuron. 2004 Feb 19;41(4):587-98. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14980207 14980207]
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Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1., Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lu Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ, Neuron. 2004 Feb 19;41(4):587-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14980207 14980207]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: kv channel-interacting protein]]
[[Category: kv channel-interacting protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:59:08 2008''

Revision as of 11:59, 20 March 2008

Image:1s1e.gif


PDB ID 1s1e

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands:
Gene: KCNIP1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)


Overview

The family of calcium binding proteins called KChIPs associates with Kv4 family K(+) channels and modulates their biophysical properties. Here, using mutagenesis and X-ray crystallography, we explore the interaction between Kv4 subunits and KChIP1. Two regions in the Kv4.2 N terminus, residues 7-11 and 71-90, are necessary for KChIP1 modulation and interaction with Kv4.2. When inserted into the Kv1.2 N terminus, residues 71-90 of Kv4.2 are also sufficient to confer association with KChIP1. To provide a structural framework for these data, we solved the crystal structures of Kv4.3N and KChIP1 individually. Taken together with the mutagenesis data, the individual structures suggest that that the Kv4 N terminus is required for stable association with KChIP1, perhaps through a hydrophobic surface interaction, and that residues 71-90 in Kv4 subunits form a contact loop that mediates the specific association of KChIPs with Kv4 subunits.

About this Structure

1S1E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1., Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lu Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ, Neuron. 2004 Feb 19;41(4):587-98. PMID:14980207

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