1s2r

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[[Image:1s2r.gif|left|200px]]<br /><applet load="1s2r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1s2r.gif|left|200px]]
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caption="1s2r, resolution 1.53&Aring;" />
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'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2'''<br />
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{{Structure
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|PDB= 1s2r |SIZE=350|CAPTION= <scene name='initialview01'>1s2r</scene>, resolution 1.53&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1S2R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SPM:'>SPM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA].
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1S2R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA].
==Reference==
==Reference==
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High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15563130 15563130]
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High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15563130 15563130]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Howerton, S B.]]
[[Category: Howerton, S B.]]
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[[Category: minor groove hydration]]
[[Category: minor groove hydration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:57:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:59:41 2008''

Revision as of 11:59, 20 March 2008

Image:1s2r.gif


PDB ID 1s2r

Drag the structure with the mouse to rotate
, resolution 1.53Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2


Overview

The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.

About this Structure

1S2R is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:15563130

Page seeded by OCA on Thu Mar 20 13:59:41 2008

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