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4igb
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707== | |
| - | + | <StructureSection load='4igb' size='340' side='right' caption='[[4igb]], [[Resolution|resolution]] 2.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4igb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_gordonii_str._challis Streptococcus gordonii str. challis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IGB FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SGO_0707 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29390 Streptococcus gordonii str. Challis])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4igb RCSB], [http://www.ebi.ac.uk/pdbsum/4igb PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The commensal Streptococcus gordonii expresses numerous surface adhesins with which it interacts with other microorganisms, host cells and salivary proteins to initiate dental plaque formation. However, this Gram-positive bacterium can also spread to non-oral sites such as the heart valves and cause infective endocarditis. One of its surface adhesins, Sgo0707, is a large protein composed of a non-repetitive N-terminal region followed by several C-terminal repeat domains and a cell wall sorting motif. Here we present the crystal structure of the Sgo0707 N-terminal domains, refined to 2.1 A resolution. The model consists of two domains, N1 and N2. The largest domain, N1, comprises a putative binding cleft with a single cysteine located in its centre and exhibits an unexpected structural similarity to the variable domains of the streptococcal Antigen I/II adhesins. The N2-domain has an IgG-like fold commonly found among Gram-positive surface adhesins. Binding studies performed on S. gordonii wild-type and a Sgo0707 deficient mutant show that the Sgo0707 adhesin is involved in binding to type-1 collagen and to oral keratinocytes. | ||
| - | + | Structural and Functional Analysis of the N-terminal Domain of the Streptococcus gordonii Adhesin Sgo0707.,Nylander A, Svensater G, Senadheera DB, Cvitkovitch DG, Davies JR, Persson K PLoS One. 2013 May 17;8(5):e63768. doi: 10.1371/journal.pone.0063768. Print 2013. PMID:23691093<ref>PMID:23691093</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Streptococcus gordonii str. challis]] | [[Category: Streptococcus gordonii str. challis]] | ||
| - | [[Category: Cvitkovitch, D G | + | [[Category: Cvitkovitch, D G]] |
| - | [[Category: Davies, J R | + | [[Category: Davies, J R]] |
| - | [[Category: Nylander, A | + | [[Category: Nylander, A]] |
| - | [[Category: Persson, K | + | [[Category: Persson, K]] |
| - | [[Category: Senadheera, D B | + | [[Category: Senadheera, D B]] |
| - | [[Category: Svensater, G | + | [[Category: Svensater, G]] |
[[Category: Adhesin]] | [[Category: Adhesin]] | ||
[[Category: Beta-sandwich fold]] | [[Category: Beta-sandwich fold]] | ||
Revision as of 12:29, 21 December 2014
Crystal structure of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707
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