4iml
From Proteopedia
(Difference between revisions)
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| - | + | ==CrossFab binding to human Angiopoietin 2== | |
| - | === | + | <StructureSection load='4iml' size='340' side='right' caption='[[4iml]], [[Resolution|resolution]] 2.93Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4iml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IML FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4imk|4imk]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iml RCSB], [http://www.ebi.ac.uk/pdbsum/4iml PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action. There is a wide variety of design alternatives for such bispecific antibodies, including the "CrossMab" format. CrossMabs contain a domain crossover in one of the antigen-binding (Fab) parts, together with the "knobs-and-holes" approach, to enforce the correct assembly of four different polypeptide chains into an IgG-like bispecific antibody. We determined the crystal structure of a hAng-2-binding Fab in its crossed and uncrossed form and show that CH1-CL-domain crossover does not induce significant perturbations of the structure and has no detectable influence on target binding. | ||
| - | + | Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain.,Fenn S, Schiller CB, Griese JJ, Duerr H, Imhof-Jung S, Gassner C, Moelleken J, Regula JT, Schaefer W, Thomas M, Klein C, Hopfner KP, Kettenberger H PLoS One. 2013 Apr 17;8(4):e61953. doi: 10.1371/journal.pone.0061953. Print 2013. PMID:23613981<ref>PMID:23613981</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Fenn, S | + | [[Category: Fenn, S]] |
| - | [[Category: Griese, J | + | [[Category: Griese, J]] |
| - | [[Category: Hopfner, K P | + | [[Category: Hopfner, K P]] |
| - | [[Category: Kettenberger, H | + | [[Category: Kettenberger, H]] |
| - | [[Category: Schiller, C | + | [[Category: Schiller, C]] |
[[Category: Antigen binding]] | [[Category: Antigen binding]] | ||
[[Category: Crossfab]] | [[Category: Crossfab]] | ||
[[Category: Human angiopoietin 2]] | [[Category: Human angiopoietin 2]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
Revision as of 12:30, 21 December 2014
CrossFab binding to human Angiopoietin 2
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