4jd8
From Proteopedia
(Difference between revisions)
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| - | + | ==Racemic-[Ru(phen)2(dppz)]2+] bound to synthetic DNA at high resolution== | |
| - | + | <StructureSection load='4jd8' size='340' side='right' caption='[[4jd8]], [[Resolution|resolution]] 1.16Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4jd8]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4e87 4e87]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JD8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TN:DELTA-RU(PHEN)2(DPPZ)+COMPLEX'>0TN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=RKP:LAMBDA-RU(PHEN)2(DPPZ)+COMPLEX'>RKP</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dx4|4dx4]], [[4e7y|4e7y]], [[4e87|4e87]], [[4e8s|4e8s]], [[4e8x|4e8x]], [[4e95|4e95]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jd8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jd8 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report an atomic resolution X-ray crystal structure containing both enantiomers of rac-[Ru(phen)2dppz](2+) with the d(ATGCAT)2 DNA duplex (phen = phenanthroline; dppz = dipyridophenazine). The first example of any enantiomeric pair crystallized with a DNA duplex shows different orientations of the Lambda and Delta binding sites, separated by a clearly defined structured water monolayer. Job plots show that the same species is present in solution. Each enantiomer is bound at a TG/CA step and shows intercalation from the minor groove. One water molecule is directly located on one phenazine N atom in the Delta-enantiomer only. | ||
| - | + | X-ray Crystal Structure of rac-[Ru(phen)2dppz](2+) with d(ATGCAT)2 Shows Enantiomer Orientations and Water Ordering.,Hall JP, Cook D, Morte SR, McIntyre P, Buchner K, Beer H, Cardin DJ, Brazier JA, Winter G, Kelly JM, Cardin CJ J Am Chem Soc. 2013 Aug 28;135(34):12652-9. doi: 10.1021/ja403590e. Epub 2013 Aug, 14. PMID:23875832<ref>PMID:23875832</ref> | |
| - | [ | + | |
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Cardin, C J | + | == References == |
| - | [[Category: Cook, D S | + | <references/> |
| - | [[Category: Hall, J P | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Cardin, C J]] | ||
| + | [[Category: Cook, D S]] | ||
| + | [[Category: Hall, J P]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: Intercalation]] | [[Category: Intercalation]] | ||
[[Category: Racemic ligand-dna]] | [[Category: Racemic ligand-dna]] | ||
Revision as of 12:31, 21 December 2014
Racemic-[Ru(phen)2(dppz)]2+] bound to synthetic DNA at high resolution
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