4ja0
From Proteopedia
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| - | + | ==Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution== | |
| - | + | <StructureSection load='4ja0' size='340' side='right' caption='[[4ja0]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4ja0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JA0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ja0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ja0 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Two important steps of the de novo purine biosynthesis pathway are catalyzed by the 5-aminoimidazole ribonucleotide carboxylase and the 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase enzymes. In most eukaryotic organisms, these two activities are present in the bifunctional enzyme complex known as PAICS. We have determined the 2.8-A resolution crystal structure of the 350-kDa invertebrate PAICS from insect cells (Trichoplusia ni) using single-wavelength anomalous dispersion methods. Comparison of insect PAICS to human and prokaryotic homologs provides insights into substrate binding and reveals a highly conserved enzymatic framework across divergent species. | ||
| - | + | Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 A resolution.,Taschner M, Basquin J, Benda C, Lorentzen E Proteins. 2013 Aug;81(8):1473-8. doi: 10.1002/prot.24296. Epub 2013 Jun 1. PMID:23553965<ref>PMID:23553965</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | |||
| + | ==See Also== | ||
| + | *[[Phosphoribosylaminoimidazole carboxylase|Phosphoribosylaminoimidazole carboxylase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bombyx mori]] | [[Category: Bombyx mori]] | ||
| - | [[Category: Basquin, J | + | [[Category: Basquin, J]] |
| - | [[Category: Benda, C | + | [[Category: Benda, C]] |
| - | [[Category: Lorentzen, E | + | [[Category: Lorentzen, E]] |
| - | [[Category: Taschner, M | + | [[Category: Taschner, M]] |
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Purine biosynthesis]] | [[Category: Purine biosynthesis]] | ||
[[Category: Saicar pure]] | [[Category: Saicar pure]] | ||
Revision as of 12:36, 21 December 2014
Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution
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