4i18

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{{STRUCTURE_4i18| PDB=4i18 | SCENE= }}
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==Crystal structure of human prolactin receptor complexed with Fab fragment==
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===Crystal structure of human prolactin receptor complexed with Fab fragment===
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<StructureSection load='4i18' size='340' side='right' caption='[[4i18]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i18]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I18 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i18 RCSB], [http://www.ebi.ac.uk/pdbsum/4i18 PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>
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*[[Antibody|Antibody]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4i18]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I18 OCA].
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[[Category: Human]]
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[[Category: Lk3 transgenic mice]]
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==Reference==
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[[Category: Duguid, E M]]
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<references group="xtra"/><references/>
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[[Category: Kouadio, J L]]
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[[Category: Duguid, E M.]]
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[[Category: Mukherjee, S]]
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[[Category: Kouadio, J L.]]
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[[Category: Mukherjee, S.]]
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]

Revision as of 12:50, 21 December 2014

Crystal structure of human prolactin receptor complexed with Fab fragment

4i18, resolution 3.24Å

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