4i0i
From Proteopedia
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| - | + | ==SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors== | |
| - | + | <StructureSection load='4i0i' size='340' side='right' caption='[[4i0i]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4i0i]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I0I FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=957:N-[(1S,2R)-1-(3,5-DIFLUOROBENZYL)-3-({1-[4-(2,2-DIMETHYLPROPYL)THIOPHEN-2-YL]CYCLOPROPYL}AMINO)-2-HYDROXYPROPYL]ACETAMIDE'>957</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i0h|4i0h]], [[4i0j|4i0j]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i0i RCSB], [http://www.ebi.ac.uk/pdbsum/4i0i PDBsum]</span></td></tr> | ||
| + | </table> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Beta secretase|Beta secretase]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Human]] |
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
| - | [[Category: Brecht, E | + | [[Category: Brecht, E]] |
| - | [[Category: Yao, N | + | [[Category: Yao, N]] |
[[Category: Aspartic protease]] | [[Category: Aspartic protease]] | ||
[[Category: Bace]] | [[Category: Bace]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Hydrolysis]] | [[Category: Hydrolysis]] | ||
Revision as of 13:08, 21 December 2014
SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
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