This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4j4q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4j4q| PDB=4j4q | SCENE= }}
+
==Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside==
-
===Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside===
+
<StructureSection load='4j4q' size='340' side='right' caption='[[4j4q]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_24038729}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.
-
==Function==
+
Opsin, a structural model for olfactory receptors?,Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. , Epub 2013 Aug 26. PMID:24038729<ref>PMID:24038729</ref>
-
[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA].
+
</div>
-
==Reference==
+
==See Also==
-
<ref group="xtra">PMID:024038729</ref><references group="xtra"/><references/>
+
*[[Rhodopsin|Rhodopsin]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Choe, H W.]]
+
[[Category: Choe, H W]]
-
[[Category: Ernst, O P.]]
+
[[Category: Ernst, O P]]
-
[[Category: Hofmann, K P.]]
+
[[Category: Hofmann, K P]]
-
[[Category: Hong, J E.]]
+
[[Category: Hong, J E]]
-
[[Category: Li, Y.]]
+
[[Category: Li, Y]]
-
[[Category: Morizumi, T.]]
+
[[Category: Morizumi, T]]
-
[[Category: Pai, E F.]]
+
[[Category: Pai, E F]]
-
[[Category: Park, J H.]]
+
[[Category: Park, J H]]
[[Category: G-protein coupled receptor]]
[[Category: G-protein coupled receptor]]
[[Category: Galpha subunit]]
[[Category: Galpha subunit]]

Revision as of 13:12, 21 December 2014

Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside

4j4q, resolution 2.65Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4j4q"
Personal tools