4i9a

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{{STRUCTURE_4i9a| PDB=4i9a | SCENE= }}
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==Crystal Structure of Sus scrofa Quinolinate Phosphoribosyltransferase in Complex with Nicotinate Mononucleotide==
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===Crystal Structure of Sus scrofa Quinolinate Phosphoribosyltransferase in Complex with Nicotinate Mononucleotide===
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<StructureSection load='4i9a' size='340' side='right' caption='[[4i9a]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23626766}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I9A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCN:NICOTINATE+MONONUCLEOTIDE'>NCN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i9a RCSB], [http://www.ebi.ac.uk/pdbsum/4i9a PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the crystal structure of porcine quinolinate phosphoribosyltransferase (QAPRTase) in complex with nicotinate mononucleotide (NAMN), which is the first crystal structure of a mammalian QAPRTase with its reaction product. The structure was determined from protein obtained from the porcine kidney. Because the full protein sequence of porcine QAPRTase was not available in either protein or nucleotide databases, cDNA was synthesized using reverse transcriptase-polymerase chain reaction to determine the porcine QAPRTase amino acid sequence. The crystal structure revealed that porcine QAPRTases have a hexameric structure that is similar to other eukaryotic QAPRTases, such as the human and yeast enzymes. However, the interaction between NAMN and porcine QAPRTase was different from the interaction found in prokaryotic enzymes, such as those of Helicobacter pylori and Mycobacterium tuberculosis. The crystal structure of porcine QAPRTase in complex with NAMN provides a structural framework for understanding the unique properties of the mammalian QAPRTase active site and designing new antibiotics that are selective for the QAPRTases of pathogenic bacteria, such as H. pylori and M. tuberculosis.
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==About this Structure==
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Crystal structure of Sus scrofa quinolinate phosphoribosyltransferase in complex with nicotinate mononucleotide.,Youn HS, Kim MK, Kang GB, Kim TG, Lee JG, An JY, Park KR, Lee Y, Kang JY, Song HE, Park I, Cho C, Fukuoka S, Eom SH PLoS One. 2013 Apr 23;8(4):e62027. doi: 10.1371/journal.pone.0062027. Print 2013. PMID:23626766<ref>PMID:23626766</ref>
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[[4i9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I9A OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023626766</ref><references group="xtra"/><references/>
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</div>
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==See Also==
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*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: An, J Y.]]
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[[Category: An, J Y]]
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[[Category: Cho, C.]]
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[[Category: Cho, C]]
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[[Category: Eom, S H.]]
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[[Category: Eom, S H]]
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[[Category: Fukuoka, S.]]
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[[Category: Fukuoka, S]]
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[[Category: Kang, J Y.]]
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[[Category: Kang, J Y]]
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[[Category: Kang, K B.]]
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[[Category: Kang, K B]]
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[[Category: Kim, M K.]]
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[[Category: Kim, M K]]
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[[Category: Kim, T G.]]
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[[Category: Kim, T G]]
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[[Category: Lee, J G.]]
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[[Category: Lee, J G]]
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[[Category: Lee, Y.]]
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[[Category: Lee, Y]]
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[[Category: Park, I.]]
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[[Category: Park, I]]
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[[Category: Park, K R.]]
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[[Category: Park, K R]]
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[[Category: Song, H E.]]
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[[Category: Song, H E]]
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[[Category: Youn, H S.]]
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[[Category: Youn, H S]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 13:12, 21 December 2014

Crystal Structure of Sus scrofa Quinolinate Phosphoribosyltransferase in Complex with Nicotinate Mononucleotide

4i9a, resolution 2.10Å

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