4lv8

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{{STRUCTURE_4lv8| PDB=4lv8 | SCENE= }}
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==Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI==
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===Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI===
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<StructureSection load='4lv8' size='340' side='right' caption='[[4lv8]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4lv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Toxoplasma_gondii_type_i Toxoplasma gondii type i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LV8 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lv5|4lv5]]</td></tr>
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==About this Structure==
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ROP5C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1209525 Toxoplasma gondii type I]), Iigp1, Irga6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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[[4lv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Toxoplasma_gondii_type_i Toxoplasma gondii type i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv8 PDBsum]</span></td></tr>
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</table>
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==Reference==
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__TOC__
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<references group="xtra"/><references/>
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</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Toxoplasma gondii type i]]
[[Category: Toxoplasma gondii type i]]
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[[Category: Boothroyd, J C.]]
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[[Category: Boothroyd, J C]]
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[[Category: Reese, M L.]]
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[[Category: Reese, M L]]
[[Category: Guanine dissociation inhibitor]]
[[Category: Guanine dissociation inhibitor]]
[[Category: Immune related gtpase]]
[[Category: Immune related gtpase]]
[[Category: Parasite effector]]
[[Category: Parasite effector]]
[[Category: Transferase-hydrolase complex]]
[[Category: Transferase-hydrolase complex]]

Revision as of 14:29, 21 December 2014

Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI

4lv8, resolution 1.72Å

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