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1sac

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[[Image:1sac.gif|left|200px]]<br /><applet load="1sac" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1sac.gif|left|200px]]
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caption="1sac, resolution 2.0&Aring;" />
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'''THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT'''<br />
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{{Structure
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|PDB= 1sac |SIZE=350|CAPTION= <scene name='initialview01'>1sac</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SAC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAC OCA].
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1SAC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAC OCA].
==Reference==
==Reference==
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Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8114934 8114934]
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Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8114934 8114934]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: amyloid protein]]
[[Category: amyloid protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:59:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:02:25 2008''

Revision as of 12:02, 20 March 2008

Image:1sac.gif


PDB ID 1sac

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT


Contents

Overview

The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.

Disease

Known disease associated with this structure: Amyloidosis, secondary, susceptibility to OMIM:[104770]

About this Structure

1SAC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934

Page seeded by OCA on Thu Mar 20 14:02:25 2008

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