4kq6
From Proteopedia
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| - | + | ==Product complex of lumazine synthase from candida glabrata== | |
| - | + | <StructureSection load='4kq6' size='340' side='right' caption='[[4kq6]], [[Resolution|resolution]] 2.24Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4kq6]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata_cbs_138 Candida glabrata cbs 138]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gef 4gef]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DLZ:1-DEOXY-1-(6,7-DIMETHYL-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL)-D-RIBITOL'>DLZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAGL0B01419g, RIB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 Candida glabrata CBS 138])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq6 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-(D-ribityl)lumazine synthase is part of the riboflavin-biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 A resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction. | ||
| - | + | Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.,Shankar M, Wilbanks SM, Nakatani Y, Monk BC, Tyndall JD Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1580-6. doi:, 10.1107/S0907444913010949. Epub 2013 Jul 20. PMID:23897480<ref>PMID:23897480</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: 6,7-dimethyl-8-ribityllumazine synthase]] | [[Category: 6,7-dimethyl-8-ribityllumazine synthase]] | ||
[[Category: Candida glabrata cbs 138]] | [[Category: Candida glabrata cbs 138]] | ||
| - | [[Category: Monk, B C | + | [[Category: Monk, B C]] |
| - | [[Category: Nakatani, Y | + | [[Category: Nakatani, Y]] |
| - | [[Category: Shankar, M | + | [[Category: Shankar, M]] |
| - | [[Category: Tyndall, J D.A | + | [[Category: Tyndall, J D.A]] |
| - | [[Category: Wilbanks, S M | + | [[Category: Wilbanks, S M]] |
[[Category: Lumazine synthase]] | [[Category: Lumazine synthase]] | ||
[[Category: Riboflavin biosynthesis]] | [[Category: Riboflavin biosynthesis]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 14:31, 21 December 2014
Product complex of lumazine synthase from candida glabrata
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