4krr
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of Drosophila WntD N-terminal domain-linker (residues 31-240)== | |
| - | + | <StructureSection load='4krr' size='340' side='right' caption='[[4krr]], [[Resolution|resolution]] 2.12Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4krr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRR FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG8458, Wnt8, wntD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4krr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4krr RCSB], [http://www.ebi.ac.uk/pdbsum/4krr PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Wnts are secreted growth factors that have critical roles in cell fate determination and stem cell renewal. The Wnt/beta-catenin pathway is initiated by binding of a Wnt protein to a Frizzled (Fzd) receptor and a coreceptor, LDL receptor-related protein 5 or 6 (LRP5/6). We report the 2.1 A resolution crystal structure of a Drosophila WntD fragment encompassing the N-terminal domain and the linker that connects it to the C-terminal domain. Differences in the structures of WntD and Xenopus Wnt8, including the positions of a receptor-binding beta hairpin and a large solvent-filled cavity in the helical core, indicate conformational plasticity in the N-terminal domain that may be important for Wnt-Frizzled specificity. Structure-based mutational analysis of mouse Wnt3a shows that the linker between the N- and C-terminal domains is required for LRP6 binding. These findings provide important insights into Wnt function and evolution. | ||
| - | + | Structural Studies of Wnts and Identification of an LRP6 Binding Site.,Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI Structure. 2013 Jul 2;21(7):1235-42. doi: 10.1016/j.str.2013.05.006. Epub 2013, Jun 20. PMID:23791946<ref>PMID:23791946</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Ahn, V E | + | [[Category: Ahn, V E]] |
| - | [[Category: Choi, H J | + | [[Category: Choi, H J]] |
| - | [[Category: Chu, M L.H | + | [[Category: Chu, M L.H]] |
| - | [[Category: Daniels, D L | + | [[Category: Daniels, D L]] |
| - | [[Category: Nusse, R | + | [[Category: Nusse, R]] |
| - | [[Category: Weis, W I | + | [[Category: Weis, W I]] |
[[Category: Extracellular]] | [[Category: Extracellular]] | ||
[[Category: Growth factor]] | [[Category: Growth factor]] | ||
Revision as of 14:39, 21 December 2014
Crystal structure of Drosophila WntD N-terminal domain-linker (residues 31-240)
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