4kzx
From Proteopedia
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| - | + | ==Rabbit 40S ribosomal subunit in complex with eIF1.== | |
| - | + | <StructureSection load='4kzx' size='340' side='right' caption='[[4kzx]], [[Resolution|resolution]] 7.81Å' scene=''> | |
| - | === | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[4kzx]] is a 35 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZX FirstGlance]. <br> | |
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF1, SUI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzx RCSB], [http://www.ebi.ac.uk/pdbsum/4kzx PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | During translation initiation in eukaryotes, the small ribosomal subunit binds messenger RNA at the 5' end and scans in the 5' to 3' direction to locate the initiation codon, form the 80S initiation complex and start protein synthesis. This simple, yet intricate, process is guided by multiple initiation factors. Here we determine the structures of three complexes of the small ribosomal subunit that represent distinct steps in mammalian translation initiation. These structures reveal the locations of eIF1, eIF1A, mRNA and initiator transfer RNA bound to the small ribosomal subunit and provide insights into the details of translation initiation specific to eukaryotes. Conformational changes associated with the captured functional states reveal the dynamics of the interactions in the P site of the ribosome. These results have functional implications for the mechanism of mRNA scanning. | ||
| - | + | The initiation of mammalian protein synthesis and mRNA scanning mechanism.,Lomakin IB, Steitz TA Nature. 2013 Jul 21. doi: 10.1038/nature12355. PMID:23873042<ref>PMID:23873042</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Ribosome 3D structures|Ribosome 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
| - | [[Category: Lomakin, I B | + | [[Category: Lomakin, I B]] |
| - | [[Category: Steitz, T A | + | [[Category: Steitz, T A]] |
[[Category: Preinitiation complex]] | [[Category: Preinitiation complex]] | ||
[[Category: Ribosome]] | [[Category: Ribosome]] | ||
[[Category: Translation initiation]] | [[Category: Translation initiation]] | ||
Revision as of 14:41, 21 December 2014
Rabbit 40S ribosomal subunit in complex with eIF1.
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