4l1m

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{{STRUCTURE_4l1m| PDB=4l1m | SCENE= }}
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==Structure of the first RCC1-like domain of HERC2==
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===Structure of the first RCC1-like domain of HERC2===
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<StructureSection load='4l1m' size='340' side='right' caption='[[4l1m]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4l1m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HERC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l1m RCSB], [http://www.ebi.ac.uk/pdbsum/4l1m PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN]] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
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*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4l1m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1M OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Dong, A.]]
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[[Category: Dong, A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Hu, J.]]
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[[Category: Hu, J]]
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[[Category: Khan, M B.]]
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[[Category: Khan, M B]]
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[[Category: Li, Y.]]
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[[Category: Li, Y]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Tempel, W.]]
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[[Category: Tempel, W]]
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[[Category: Tong, Y.]]
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[[Category: Tong, Y]]
[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
[[Category: Herc2]]
[[Category: Herc2]]
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[[Category: Rld]]
[[Category: Rld]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 

Revision as of 14:42, 21 December 2014

Structure of the first RCC1-like domain of HERC2

4l1m, resolution 2.60Å

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