4kui

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{{STRUCTURE_4kui| PDB=4kui | SCENE= }}
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==Crystal structure of N-terminal acetylated yeast Sir3 BAH domain==
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===Crystal structure of N-terminal acetylated yeast Sir3 BAH domain===
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<StructureSection load='4kui' size='340' side='right' caption='[[4kui]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23934152}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4kui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AYA:N-ACETYLALANINE'>AYA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kud|4kud]], [[4kul|4kul]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIR3, CMT1, MAR2, STE8, YLR442C, L9753.10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kui RCSB], [http://www.ebi.ac.uk/pdbsum/4kui PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In Saccharomyces cerevisiae, acetylation of the Sir3 N terminus is important for transcriptional silencing. This covalent modification promotes the binding of the Sir3 BAH domain to the nucleosome, but a mechanistic understanding of this phenomenon is lacking. By X-ray crystallography, we show here that the acetylated N terminus of Sir3 does not interact with the nucleosome directly. Instead, it stabilizes a nucleosome-binding loop in the BAH domain.
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==Function==
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Nalpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain.,Yang D, Fang Q, Wang M, Ren R, Wang H, He M, Sun Y, Yang N, Xu RM Nat Struct Mol Biol. 2013 Aug 11. doi: 10.1038/nsmb.2637. PMID:23934152<ref>PMID:23934152</ref>
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[[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4kui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUI OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023934152</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Fang, Q.]]
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[[Category: Fang, Q]]
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[[Category: He, M.]]
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[[Category: He, M]]
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[[Category: Ren, R.]]
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[[Category: Ren, R]]
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[[Category: Sun, Y.]]
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[[Category: Sun, Y]]
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[[Category: Wang, H.]]
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[[Category: Wang, H]]
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[[Category: Wang, M.]]
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[[Category: Wang, M]]
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[[Category: Xu, R M.]]
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[[Category: Xu, R M]]
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[[Category: Yang, D.]]
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[[Category: Yang, D]]
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[[Category: Yang, N.]]
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[[Category: Yang, N]]
[[Category: Bah domain]]
[[Category: Bah domain]]
[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Silencing]]
[[Category: Silencing]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 14:54, 21 December 2014

Crystal structure of N-terminal acetylated yeast Sir3 BAH domain

4kui, resolution 1.85Å

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