4k67

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{{STRUCTURE_4k67| PDB=4k67 | SCENE= }}
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==Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005 complexed with human receptor analog LSTc==
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===Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005 complexed with human receptor analog LSTc===
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<StructureSection load='4k67' size='340' side='right' caption='[[4k67]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23641058}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4k67]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/indonesia/5/2005(h5n1)) Influenza a virus (a/indonesia/5/2005(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K67 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k62|4k62]], [[4k63|4k63]], [[4k64|4k64]], [[4k65|4k65]], [[4k66|4k66]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=400788 Influenza A virus (A/Indonesia/5/2005(H5N1))])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k67 RCSB], [http://www.ebi.ac.uk/pdbsum/4k67 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Recent studies have identified several mutations in the hemagglutinin (HA) protein that allow the highly pathogenic avian H5N1 influenza A virus to transmit between mammals by airborne route. Here, we determined the complex structures of wild-type and mutant HAs derived from an Indonesia H5N1 virus bound to either avian or human receptor sialic acid analogs. A cis/trans conformational change in the glycosidic linkage of the receptor analog was observed, which explains how the H5N1 virus alters its receptor binding preference. Furthermore, the mutant HA possessed low affinities for both avian and human receptors. Our findings provide a structural and biophysical basis for the H5N1 adaptation to acquire human, but maintain avian, receptor binding properties.
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==About this Structure==
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An Airborne Transmissible Avian Influenza H5 Hemagglutinin Seen at the Atomic Level.,Zhang W, Shi Y, Lu X, Shu Y, Qi J, Gao GF Science. 2013 May 2. PMID:23641058<ref>PMID:23641058</ref>
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[[4k67]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/indonesia/5/2005(h5n1)) Influenza a virus (a/indonesia/5/2005(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K67 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023641058</ref><references group="xtra"/><references/>
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</div>
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[[Category: Gao, G F.]]
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[[Category: Lu, X.]]
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==See Also==
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[[Category: Shi, Y.]]
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*[[Hemagglutinin|Hemagglutinin]]
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[[Category: Shu, Y.]]
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== References ==
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[[Category: Zhang, W.]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gao, G F]]
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[[Category: Lu, X]]
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[[Category: Shi, Y]]
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[[Category: Shu, Y]]
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[[Category: Zhang, W]]
[[Category: Membrane fusion]]
[[Category: Membrane fusion]]
[[Category: Viral protein]]
[[Category: Viral protein]]
[[Category: Virus attachment]]
[[Category: Virus attachment]]

Revision as of 14:57, 21 December 2014

Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005 complexed with human receptor analog LSTc

4k67, resolution 2.70Å

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