4lvp
From Proteopedia
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| - | + | ==Crystal structure of IFT81 N-terminal domain== | |
| - | === | + | <StructureSection load='4lvp' size='340' side='right' caption='[[4lvp]], [[Resolution|resolution]] 2.32Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4lvp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVP FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TA0:TANTALUM'>TA0</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lvr|4lvr]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFT81, CHLREDRAFT_138649 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 Chlamydomonas reinhardtii])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvp RCSB], [http://www.ebi.ac.uk/pdbsum/4lvp PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Intraflagellar transport (IFT) of ciliary precursors such as tubulin from the cytoplasm to the ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most eukaryotic cells. However, the molecular mechanisms of IFT are poorly understood. Here, we found that the two core IFT proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74. Knockdown of IFT81 and rescue experiments with point mutants showed that tubulin binding by IFT81 was required for ciliogenesis in human cells. | ||
| - | + | Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.,Bhogaraju S, Cajanek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E Science. 2013 Aug 30;341(6149):1009-12. doi: 10.1126/science.1240985. PMID:23990561<ref>PMID:23990561</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chlamydomonas reinhardtii]] | [[Category: Chlamydomonas reinhardtii]] | ||
| - | [[Category: Bhogaraju, S | + | [[Category: Bhogaraju, S]] |
[[Category: Ch domain]] | [[Category: Ch domain]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
[[Category: Tubulin/microtubule]] | [[Category: Tubulin/microtubule]] | ||
Revision as of 14:57, 21 December 2014
Crystal structure of IFT81 N-terminal domain
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