1sfk

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[[Image:1sfk.gif|left|200px]]<br /><applet load="1sfk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1sfk.gif|left|200px]]
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caption="1sfk, resolution 3.20&Aring;" />
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'''Core (C) protein from West Nile Virus, subtype Kunjin'''<br />
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{{Structure
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|PDB= 1sfk |SIZE=350|CAPTION= <scene name='initialview01'>1sfk</scene>, resolution 3.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=PG4:TETRAETHYLENE GLYCOL'>PG4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Core (C) protein from West Nile Virus, subtype Kunjin'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SFK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Kunjin_virus Kunjin virus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=PG4:'>PG4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFK OCA].
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1SFK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Kunjin_virus Kunjin virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFK OCA].
==Reference==
==Reference==
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West Nile virus core protein; tetramer structure and ribbon formation., Dokland T, Walsh M, Mackenzie JM, Khromykh AA, Ee KH, Wang S, Structure. 2004 Jul;12(7):1157-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15242592 15242592]
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West Nile virus core protein; tetramer structure and ribbon formation., Dokland T, Walsh M, Mackenzie JM, Khromykh AA, Ee KH, Wang S, Structure. 2004 Jul;12(7):1157-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15242592 15242592]
[[Category: Kunjin virus]]
[[Category: Kunjin virus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: alpha helix]]
[[Category: alpha helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:01:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:04:17 2008''

Revision as of 12:04, 20 March 2008

Image:1sfk.gif


PDB ID 1sfk

Drag the structure with the mouse to rotate
, resolution 3.20Å
Ligands: , , and
Coordinates: save as pdb, mmCIF, xml



Core (C) protein from West Nile Virus, subtype Kunjin


Overview

We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four alpha helices and forms dimers that are organized into tetramers. The tetramers form extended filamentous ribbons resembling the stacked alpha helices seen in HEAT protein structures.

About this Structure

1SFK is a Single protein structure of sequence from Kunjin virus. Full crystallographic information is available from OCA.

Reference

West Nile virus core protein; tetramer structure and ribbon formation., Dokland T, Walsh M, Mackenzie JM, Khromykh AA, Ee KH, Wang S, Structure. 2004 Jul;12(7):1157-63. PMID:15242592

Page seeded by OCA on Thu Mar 20 14:04:17 2008

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