4jqf
From Proteopedia
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| - | + | ==Structure of the C-terminal domain of human telomeric Stn1== | |
| - | + | <StructureSection load='4jqf' size='340' side='right' caption='[[4jqf]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4jqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JQF FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4joi|4joi]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OBFC1, STN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jqf RCSB], [http://www.ebi.ac.uk/pdbsum/4jqf PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The identification of the human homologue of the yeast CST in 2009 posed a new challenge in our understanding of the mechanism of telomere capping in higher eukaryotes. The high-resolution structure of the human Stn1-Ten1 (hStn1-Ten1) complex presented here reveals that hStn1 consists of an OB domain and tandem C-terminal wHTH motifs, while hTen1 consists of a single OB fold. Contacts between the OB domains facilitate formation of a complex that is strikingly similar to the replication protein A (RPA) and yeast Stn1-Ten1 (Ten1) complexes. The hStn1-Ten1 complex exhibits non-specific single-stranded DNA activity that is primarily dependent on hStn1. Cells expressing hStn1 mutants defective for dimerization with hTen1 display elongated telomeres and telomere defects associated with telomere uncapping, suggesting that the telomeric function of hCST is hTen1 dependent. Taken together the data presented here show that the structure of the hStn1-Ten1 subcomplex is conserved across species. Cell based assays indicate that hTen1 is critical for the telomeric function of hCST, both in telomere protection and downregulation of telomerase function. | ||
| - | + | Structure of the human telomeric stn1-ten1 capping complex.,Bryan C, Rice C, Harkisheimer M, Schultz DC, Skordalakes E PLoS One. 2013 Jun 24;8(6):e66756. doi: 10.1371/journal.pone.0066756. Print 2013. PMID:23826127<ref>PMID:23826127</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bryan, C F | + | [[Category: Bryan, C F]] |
| - | [[Category: Harkisheimer, M | + | [[Category: Harkisheimer, M]] |
| - | [[Category: Rice, C T | + | [[Category: Rice, C T]] |
| - | [[Category: Schultz, D | + | [[Category: Schultz, D]] |
| - | [[Category: Skordalakes, E | + | [[Category: Skordalakes, E]] |
[[Category: Ctc1]] | [[Category: Ctc1]] | ||
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Pol alpha]] | [[Category: Pol alpha]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 15:16, 21 December 2014
Structure of the C-terminal domain of human telomeric Stn1
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